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Specification

Concerning Product:
Article number 130405NLE
Trade name / designation / denomination Vitamin B2 5-Natriumphosphat, EP
CAS number 130-40-5
Other names / synonyms•RIBOFLAVIN-5?-PHOSPHATE; •Riboflavin 5'-Phosphate Sodium, Dihydrate, Electrophoresis Grade; •Riboflavin 5'-Phosphate Sodium, Dihydrate, FCC; •Riboflavin 5'-Phosphate Sodium, USP; •Riboflavin 5'-monophosphate sodium salt hydrate; •Riboflavin 5'-phosphate sodium salt hydrate; •riboflavin 5'-(sodium hydrogen phosphate); •sodium [(2S,3R,4R)-5-(7,8-dimethyl-2,4-dioxo-10-benzo[g]pteridinyl)-2,3,4-trihydroxypentyl] hydrogen phosphate;
EC number204-988-6
Customs tariff number / CN code / TARIC29362300
Molecular weight [g / mol]478.325631
FormulaC17H20N4NaO9P


Parameter Test Method Specification Unit

Organoleptic test
Appearance A Yellow or Organge Yellow Crystalline Powder, Hygroscopic.

Physical parameter
Loss on drying USP ≤ 7,5 %
Loss on drying EP/BP/E101 (ii) ≤ 8 %
pH value 1 % Solution 5,0  –  6,5
Specific Optical Rotation E101 (ii) 38  –  42 °
Specific Optical Rotation EP/BP 38  –  43 °
Specific Optical Rotation USP 37  –  42 °
Solubility Soluble in water, very slightly soluble in ethanol (96 %)

Identity
Assay USP Riboflavin (o.d.b.) 73  –  79 %
Assay EP/BP Riboflavin (o.d.b.) 73  –  79 %
Assay E101 (ii) total coloring matters calculated as C17H20N4NaO9P.2H2O ≥ 95 %
Identification EP/BP (A): Absorption test: 580  –  640
Identification EP/BP (B) by HPLC test: The principle peak in the chromatogram obtained with the test of solution is similar in position and approximate size to the principle peak in the chŕomatogram obtained with the reference soltion b
Identification USP/EP/BP (C) Fluorescence test: The lower layer exhibits yellow fluorescence
Identification (D) Reaction of Sodium Salt u. Phosphate: The filtrate gives reaction of sodium and reaction fo phosphate
Infrared absorbtion spectrometry E 101 (ii) A375/A267 0,30  –  0,34
Infrared absorbtion spectrometry E 101 (ii) A444/A267 0,35  –  0,40

Impurities
Heavy Metals (as Pb) ≤ 10 mg/kg
Phosphate (PO4) E101 (ii) Inorganic ≤ 1,5 %
Phosphate (PO4) EP/BP Inorganic ≤ 1,0 %
Sulphated ash E101 (ii) ≤ 25 %
Impurity EP/BP (E): The filtrate is not more intersely coloured than reference solution BY 6
Impurity aromatic amines (as aniline): ≤ 70 ppm
Impurity USP Lumiflavine: ≤ 0,025 absorbance
Related substances Free Riboflavin ≤ 6,0 %
Related substances Riboflavin Diphosphate ≤ 6,0 %

Residual Solvents
Residual solvents Methanol: ≤ 0,3 %

Elemental Impurities
Arsenic (As) ≤ 3 mg/kg
Cadmium (Cd) ≤ 1 mg/kg
Mercury (Hg) ≤ 0,1 mg/kg
Lead (Pb) ≤ 2 mg/kg

Organic volatile impurities
Org. volat. Imp. Total as Mentol ≤ 3000 ppm

Microbiological data
Escherichia Coli. in 1 gm: Absent CFU/g
Total Plate Count ≤ 1000 CFU/gm
Yeast and Mould ≤ 100 CFU/g
Annotation:
o.d.b. = on dried basis / auf getrockneter Basis


Supplemental information:

Shelf life: 2 years

Storage conditions: Protect from light and store cool and dry in well-closed original packaging. The temperature should not exceed 25 °C.

Regional origin: IND


Chemische Werke Hommel GmbH & Co.KG
This document was generated electronically and is valid without signature.
Waltrop, 03. Jan. 2022
We only confirm that we took over the data from our supplier accordingly. Despite careful working, errors in the takeover are not totally excluded. Some or all parts off the document may be translated due to our best knowledge from the original to give a better understanding. If you have any questions about specific details, please call us directly. Unless otherwise marked, these data do not originate from us and have not been tested by us on the correctness. The above information corresponds to the present state of our knowledge and is intended as a general description of our products and their possible applications. We make no warranties, expressed or implied, as to the information's accuracy, adequacy, sufficiency or freedom from defect and assumes no liability in connection with any use of this information. Any user of this product is responsible for determining the suitability of our products for its particular application. The foregoing information does not absolve the buyer of its own tests. Observing existing laws and regulations, is the responsibility of the buyer of our product. Nothing included in this information waives any of our General Terms and Conditions of Sale, which control unless it agrees other in writing. Any existing intellectual/industrial property rights must be observed. Due to possible changes in our products and applicable national and international regulations and laws, the status of our products could change. Material Safety Data Sheets providing safety precautions, that should be observed when handling or storing our products, are available upon request and are provided in compliance with applicable law. The user should obtain and review the applicable Material Safety Data Sheet information before handling any of these products. For additional information, please contact us.


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